Article
Structural Insights into Tanc1/2 Autoinhibition and Their Implications for NDD Pathogenesis.
Journal of molecular biology - 1 Aug 2026
Zhong Dengqin, Xue Chenyang, Lyu Mengjie, Zhang Dongsheng, Chen Qiangou, Li Jun, Wang Yanan, Liu An, Xie Wei, Cui Yongping, Xiao Kang, Liu Zhongmin, Liu Wei
Abstract excerpt
Tanc1 and Tanc2 are synaptic scaffold proteins with high structural similarity but distinct expression patterns and functions. Although accumulating evidence points to important divergent roles of Tanc1 and Tanc2 in neural development, the precise molecular mechanisms governing their activity (e.g., autoinhibition and activation) and their pathogenic pathways in neurodevelopmental disorders remain poorly defined....
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