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Overexpression of Parkin in the Neuronal Progenitor Cells from a Patient with Parkinson's Disease Shifts the Transcriptome Towards the Normal State.

Molecular neurobiology - 1 Jun 2023

Lebedeva Olga, Poberezhniy Daniil, Novosadova Ekaterina, Gerasimova Tatiana, Novosadova Lyudmila, Arsenyeva Elena, Stepanenko Ekaterina, Shimchenko Darya, Volovikov Egor, Anufrieva Ksenia, Illarioshkin Sergey, Lagarkova Maria, Grivennikov Igor, Tarantul Vyacheslav, Nenasheva Valentina

Abstract excerpt

Parkinson's disease (PD) is a neurodegenerative pathology caused by the progressive loss of dopaminergic neurons in the substantia nigra. Juvenile PD is known to be strongly associated with mutations in the PARK2 gene encoding E3 ubiquitin ligase Parkin. Despite numerous studies, molecular mechanisms that trigger PD remain largely unknown. Here, we compared the transcriptome of the neural progenitor (NP) cell...

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PMID: 36884134
DOI: 10.1007/s12035-023-03293-z

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