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Article

Impact of Copy Number Alterations on Human Papillomavirus (HPV)-Induced and HPV-Independent Penile Cancers.

Laboratory investigation; a journal of technical methods and pathology - 1 Jul 2026

Ermakov Mikhail S, Regauer Sigrid, Kashofer Karl

Abstract excerpt

PURPOSE: Penile squamous cell carcinomas (SCC) develop via transforming human papillomavirus (HPV) infection or independent of HPV. The association of copy number alterations (CNA) affecting chromosome arms, amplifications or deletions of tumor suppressor/oncogenes with HPV status and somatic mutations is largely unknown. MATERIALS AND METHODS: CNA in 121 penile SCC (52% HPV associated, 48% HPV independent) were...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42031074
DOI: 10.1016/j.labinv.2026.106129

Genes

MYC
ATM
CDKN2A
EGFR
PIK3CA
TP53
ARHGEF12
BAP1
BCL9L
CDKN1A
FANCD2
FGFR3
HEY1
HRAS
MTAP
NRG1
RAD21
RB1
SOX2
TP63
VHL
WRN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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