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Nuclear TRAF3 is a negative regulator of CREB in B cells

11 Jan 2016

Abstract excerpt

The adaptor protein TNF receptor-associated factor 3 (TRAF3) regulates signaling through B-lymphocyte receptors, including CD40, BAFF receptor, and Toll-like receptors, and also plays a critical role inhibiting B-cell homoeostatic survival. Consistent with these findings, loss-of-function human TRAF3 mutations are common in B-cell cancers, particularly multiple myeloma and B-cell lymphoma. B cells of...

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PMID: 26755589
DOI: 10.1073/pnas.1514586113

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