Article

Single-cell quantification of senescence burden reveals cell type-specific ageing dynamics across organs

2025-11-14

Abstract excerpt

Cellular senescence, a hallmark of ageing, drives tissue dysfunction by promoting inflammation and fuelling disease. Yet, the dynamics of senescent cell accumulation across tissues and their cell type identity remain poorly understood. Here, we introduce the first, single-cell, protein-level approach, combining multiple senescence markers for the identification and quantification of senescent cells across multiple...

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Literature Corpus work: 2634723a-b130-5e26-af27-13b0618c3772
DOI: 10.1101/2025.11.14.688272

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