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Blood mitochondrial heteroplasmic variants and cognitive performance in late midlife: REGARDS study.

BMC neurology - 21 Apr 2026

Prada Diddier, Morava-Kozicz Eva, Rajendrakumar Aravind Lathika, Kupsco Allison, Lesseur Corina, Irizar Haritz, Cantú-de-Leon David, García-Cuellar Claudia, Ramírez Andrea, González-Ruíz Jonathan, Horowitz Carol R, Cushman Mary, Manly Jennifer, Judd Suzanne, Bagiella Emilia, Baccarelli Andrea, Parks Robbie

Abstract excerpt

BACKGROUND: Studies linking mitochondrial DNA (mtDNA) variants to cognition yielded inconsistent findings, and the underlying mechanisms remain unclear. We investigated whether mtDNA heteroplasmic variants were associated with cognitive outcomes, including the Montreal Cognitive Assessment (MoCA), in 197 late midlife adults from the Reasons for Geographic and Racial Differences in Stroke (REGARDS) cohort with...

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Cognition
Cohort Studies
DNA, Mitochondrial
Genetic Variation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mental Status and Dementia Tests

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PMID: 42015047
DOI: 10.1186/s12883-026-04857-x
PMCID: PMC13101111

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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