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Exploring mitochondrial blood-based and genetic markers in older adults with mild cognitive impairment and remitted major depressive disorder.

Translational psychiatry - 29 Oct 2024

Choi Jaehyoung, Beroncal Erika L, Chernega Timofei, Brooks Heather J, Kennedy James L, Fisher Corinne E, Flint Alastair J, Herrmann Nathan, Lanctôt Krista L, Mah Linda, Mulsant Benoit H, Pollock Bruce G, Rajji Tarek K, Andreazza Ana C

Abstract excerpt

Mild cognitive impairment (MCI) is a prodromal stage in aging to possible progression to Alzheimer's disease and related dementia (ADRD), where co-occurrence of major depressive disorder (MDD) accelerates the progression. Metabolic and mitochondrial abnormalities in ADRD and other neurodegenerative disorders have been widely suggested, while possible mitochondrial dysfunction has been associated with...

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PMID: 39468012
DOI: 10.1038/s41398-024-03155-9
PMCID: PMC11519657

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