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Article

Functional requirement for Dicer helicase arginine methylation in 26 G siRNA biogenesis and oocyte meiotic program.

Nature communications - 21 Apr 2026

Newkirk Nick, Chen Shin-Yu, Furuta Tokiko, Trimmer Kenneth A, Shi Leilei, Stratton Sabrina, Li Hongyuan, Cheng Xiaodong, Bedford Mark T, Arur Swathi

Abstract excerpt

Spatiotemporal regulation of Dicer is essential for small RNA biogenesis and fertility, yet how its helicase domain is controlled remains unclear. Using Caenorhabditis elegans, we identify a regulatory role for the arginine-rich GRARR motif within helicase domain motif VI of DCR-1. Mutating conserved arginines in this sequence disrupts maternal 26 G endo-siRNA production, impairs oocyte meiosis I and II, and...

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Identifiers

PMID: 42014716
DOI: 10.1038/s41467-026-72069-5
PMCID: PMC13284205

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