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Article

TWSG1 variation identifies a ustekinumab-response phenotype in patients with inflammatory bowel disease.

Pharmacogenetics and genomics - 1 Jul 2026

Alkhalifa Mohammed, Dela Cruz Gio R, Ponich Terry, Gregor James C, Yan Brian, Khanna Reena, McIntosh Keith, Beaton Melanie D, Kim Richard B, Wilson Aze

Abstract excerpt

OBJECTIVES: A genome-wide association study identified that genetic variation in the twisted gastrulation protein homolog-1 gene ( TWSG1 rs7242593) was linked to early clinical remission in ustekinumab-exposed patients in the UNITI clinical trials. We aimed to confirm if a single nucleotide variation (SNV) in the TWSG1 gene is associated with clinical remission in inflammatory bowel disease (IBD) patients on...

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Identifiers

PMID: 42011099
DOI: 10.1097/FPC.0000000000000602

Genes

TWSG1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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