Article
Lifestyle modifies the associations of early-life smoking behaviors and genetic susceptibility with type 2 diabetes: A prospective cohort study involving 433,872 individuals from UK Biobank.
Diabetes & metabolic syndrome - 1 Jul 2024
Jiang Xuanwei, Yang Guangrui, Feng Nannan, Du Xihao, Xu Lan, Zhong Victor W
Abstract excerpt
BACKGROUND: To investigate whether and what lifestyle factors in later life modify the associations of early-life smoking behaviors and genetic susceptibility with type 2 diabetes (T2D). METHODS: In the UK Biobank, in utero tobacco exposure (n = 354,493) and age of smoking initiation (n = 353,557) were self-reported. A composite lifestyle score was calculated based on diet, physical activity, nicotine exposure,...
Topics
- Humans
- Diabetes Mellitus, Type 2
- Female
- Prospective Studies
- Life Style
- Male
- Genetic Predisposition to Disease
- Smoking
- Follow-Up Studies
- United Kingdom