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ACT-ON: Assisted cascade testing via outreach and navigation - Real-world experience with clinician-facilitated cascade testing.

Gynecologic oncology - 1 Apr 2026

Epstein Emily S, Primiano Michelle, Ozarowski Amanda Laterza, Karimaghaie Tina, Kirby Max, Lopez Steve, Rauh-Hain Jose Alejandro, Wilke Roni, Moss Haley A, Brewer Jesse, Levi Sarah R, LaRosa Taylor, Kalyan Alissa, Llenas Ashley, Marchal Susan, Song Li Bing, Ahsan Muhammad Danyal, Sharaf Ravi N, Frey Melissa K

Abstract excerpt

OBJECTIVES: Cascade genetic testing is a pragmatic, high-impact strategy for cancer prevention; however, under the current patient-mediated model, only one-third of relatives complete testing. Clinician-facilitated cascade testing represents a promising alternative, though questions remain regarding scalability and effectiveness in real-world settings. We aimed to evaluate the outcomes of a real-world,...

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PMID: 42000374
DOI: 10.1016/j.ygyno.2026.01.775

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