Article
Cascade Testing for Hereditary Cancer Syndromes: Should We Move Toward Direct Relative Contact? A Systematic Review and Meta-Analysis.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 Dec 2022
Frey Melissa K, Ahsan Muhammad Danyal, Bergeron Hannah, Lin Jenny, Li Xuan, Fowlkes Rana K, Narayan Priyanka, Nitecki Roni, Rauh-Hain Jose Alejandro, Moss Haley A, Baltich Nelson Becky, Thomas Charlene, Christos Paul J, Hamilton Jada G, Chapman-Davis Eloise, Cantillo Evelyn, Holcomb Kevin, Kurian Allison W, Lipkin Steven, Offit Kenneth, Sharaf Ravi N
Abstract excerpt
PURPOSE: Evidence-based guidelines recommend cascade genetic counseling and testing for hereditary cancer syndromes, providing relatives the opportunity for early detection and prevention of cancer. The current standard is for patients to contact and encourage relatives (patient-mediated contact) to undergo counseling and testing. Direct relative contact by the medical team or testing laboratory has shown promise...
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