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Cascade Chatbot: A Scalable Approach to Family-Based Genetic Testing for Hereditary Cancer Syndromes.

JCO clinical cancer informatics - 1 Mar 2026

Davis Rivera Lauren B, Mitchell Lauren, Ahsan Muhammad Danyal, Chandler Isabelle, Epstein Emily S, Borsato Emerson P, Allen Caitlin, Kaphingst Kimberly A, Bradshaw Richard L, Del Fiol Guilherme, Kawamoto Kensaku, Madeo Anne C, Sharaf Ravi N, Frey Melissa K

Abstract excerpt

PURPOSE: Cascade genetic testing enables identification of relatives at risk of hereditary cancer syndromes, creating opportunities for early detection and prevention. However, uptake of cascade testing remains low, with approximately one-third of eligible relatives completing testing, largely because of reliance on patient-mediated communication. Although clinician-mediated outreach has demonstrated improved...

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Family
Genetic Counseling
Genetic Predisposition to Disease
Genetic Testing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplastic Syndromes, Hereditary

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PMID: 41802247
DOI: 10.1200/CCI-25-00321
PMCID: PMC13228992

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Cascade Chatbot: A Scalable Approach to Family-Based Genetic Testing for Hereditary Cancer Syndromes.PMID 41802247Read ↗

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