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Cascade genetic testing for hereditary cancer syndromes: a review of barriers and breakthroughs.

Familial cancer - 1 Jun 2024

Levine Rachel, Kahn Ryan M, Perez Luiza, Brewer Jesse, Ratner Samantha, Li Xuan, Yeoshoua Effi, Frey Melissa K

Abstract excerpt

Germline genetic sequencing is now at the forefront of cancer treatment and preventative medicine. Cascade genetic testing, or the testing of at-risk relatives, is extremely promising as it offers genetic testing and potentially life-saving risk-reduction strategies to a population exponentially enriched for the risk of carrying a cancer-associated pathogenic variant. However, many relatives do not complete...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 38530571
DOI: 10.1007/s10689-024-00373-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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