Organoid phenotypic screening identified glycyrrhizin that confers protection against tumor necrosis factor-induced cell death.

Abstract excerpt

Human organoids are considered physiological models that reflect human physiology; however, their applications in drug screening studies are limited. To develop a fundamental treatment for recurrent Crohn's disease (CD), in which tumor necrosis factor (TNF) is a key pathogenic factor, we conducted phenotypic drug screening to prevent TNF-induced cell death in human intestinal epithelial organoids. Glycyrrhizin, a...

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• Apoptosis
• Caspase 8
• Cell Death
• Cell Line
• Drug Evaluation, Preclinical