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Article

High-gradient magnetic separation chip-based small extracellular vesicle isolation for noninvasive subtyping of primary aldosteronism.

Science advances - 17 Apr 2026

Wang Dong, Zhou Jun, Chen Zhixin, Yang Junyuan, Li Yingjie, Sun Shiwei, Qiu Dongxu, Wang Yao, Zhang Yushi, Yang Mingzhu

Abstract excerpt

Primary aldosteronism (PA), a leading cause of secondary hypertension, remains vastly underdiagnosed due to unreliable screening tools. We developed an integrated platform combining a high-gradient magnetic separation three-dimensional (HGMS-3D) chip and locked nucleic acid (LNA)-enhanced droplet digital polymerase chain reaction (ddPCR) for noninvasive detection of potassium inwardly rectifying channel subfamily...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41996506
DOI: 10.1126/sciadv.aeb4949
PMCID: PMC13089352

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KCNJ5

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