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Article

A nano-magnetic size selective cfDNA extraction platform for liquid biopsy with enhanced precision.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences - 30 May 2022

Liu Ying, Cheng Li, Wang Guanghui, Lv Jiahui, He Yifei, Shao Pan-Lin, Hu Ruibin, Xiao Hongjun, Tang Jiahu, Niu Dan, Yang Jingkai, Tang Zhongrong, Xu Ziyi, Liu Yiyi, Li Yi, Song Kun, Wu Benqing, Zhang Bo

Abstract excerpt

As an emerging biomarker, cell-free DNA (cfDNA) carries crucial genetic information for the diagnosis of hereditary disease and cancer. However, test accuracy was severely compromised by the low abundance of cell-free DNA in peripheral blood, frequently diluted by genomic DNA released from white blood cells, resulting in sample rejection, test inaccuracy, and restricted clinical utility. Herein we report a novel...

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PMID: 35472714
DOI: 10.1016/j.jchromb.2022.123236

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