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Article

P53-independent partial restoration of the p53 pathway in tumors with mutated p53 through ATF4 transcriptional modulation by ERK1/2 and CDK9.

Neoplasia (New York, N.Y.) - 1 Mar 2021

Tian Xiaobing, Ahsan Nagib, Lulla Amriti, Lev Avital, Abbosh Philip, Dicker David T, Zhang Shengliang, El-Deiry Wafik S

Abstract excerpt

A long-term goal in the cancer-field has been to develop strategies for treating p53-mutated tumors. A novel small-molecule, PG3-Oc, restores p53 pathway-signaling in tumor cells with mutant-p53, independently of p53/p73. PG3-Oc partially upregulates the p53-transcriptome (13.7% of public p53 target-gene dataset; 15.2% of in-house dataset) and p53-proteome (18%, HT29; 16%, HCT116-p53-/-). Bioinformatic analysis...

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Identifiers

PMID: 33582407
DOI: 10.1016/j.neo.2021.01.004
PMCID: PMC7890376

Genes

ATF4
CDK9
DRAM1
MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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