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Article

Dietary effect on glucose homeostasis is modulated by a loss-of-function variant in the sucrase-isomaltase gene: a randomised, dietary crossover intervention in Inuit.

Diabetologia - 1 Jul 2026

Senftleber Ninna, Christensen Marie Mathilde B, Carstensen Bendix, Stæger Frederik Filip, Frøst Michael B, Gillum Matthew P, Hansen Torben, Jørgensen Marit E

Abstract excerpt

AIMS/HYPOTHESIS: Homozygous carriers of a loss-of-function variant in the sucrase-isomaltase (SI) gene (c.273_274delAG) are unable to digest sucrose and parts of starch. The variant is common only in Indigenous Arctic populations such as the Greenlandic Inuit and has been associated with a healthier metabolic profile. In a unique gene-diet intervention, we aimed to study whether the SI genotype modulates the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41995844
DOI: 10.1007/s00125-026-06723-4
PMCID: PMC13236788

Genes

SI
TBC1D4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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Dietary effect on glucose homeostasis is modulated by a loss-of-function variant in the sucrase-isomaltase gene: a randomised, dietary crossover intervention in Inuit.PMID 41995844Read ↗

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