Long-read KIR genotyping reveals donor KIR/HLA polymorphisms linked to posttransplant relapse in T-cell malignancies.

doi:10.1182/bloodadvances.2025019066

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Long-read KIR genotyping reveals donor KIR/HLA polymorphisms linked to posttransplant relapse in T-cell malignancies.

Blood advances - 14 Jul 2026

Morita Mari, Kawaguchi Shuji, Shindo Takero, Izumi Kiyotaka, Shimizu Masakazu, Inadomi Yuichi, Kanda Junya, Watanabe Mizuki, Takahashi Meiko, Tsujimura Taro, Tarumoto Shoko, Yamamoto Takuya, Kato Koji, Tanaka Hidenori, Morishima Satoko, Morishima Yasuo, Nakano Nobuaki, Hayashi Masayasu, Miyazaki Yasuhiko, Imada Kazunori, Higuchi Yusuke, Yonezawa Akihito, Suehiro Youko, Yoshimitsu Makoto, Doki Noriko, Katayama Yuta, Hasegawa Yuta, Serizawa Kentaro, Ichinohe Tatsuo, Fukuda Takahiro, Onizuka Makoto, Atsuta Yoshiko, Takaori-Kondo Akifumi, Matsuda Fumihiko

Abstract excerpt

ABSTRACT: Donor polymorphisms in killer-cell immunoglobulin-like receptor (KIR) and HLA shape natural killer (NK) cell activity, which may influence relapse risk after allogeneic hematopoietic stem cell transplantation (allo-HSCT). However, association studies have been limited by insufficient allele-level KIR genotyping. Using high-resolution, long-read genotyping of 15 KIR genes, we performed an unbiased...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41995743
DOI: 10.1182/bloodadvances.2025019066
PMCID: PMC13319384

Genes

KIR3DL1
KIR3DS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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