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Article

Severe traumatic injury is associated with profound changes in DNA methylation

1 Nov 2024

Abstract excerpt

Whether DNA methylation changes follow human physical trauma is uncertain. We aimed to investigate if severe trauma was associated with DNA methylation changes. In a prospective, observational, clinical study, we included severely injured adults and adults undergoing elective surgery (controls). Blood was obtained from trauma patients (n = 60) immediately- and 30-45 days post-trauma, and from surgical patients (n...

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PMID: 39487175
DOI: 10.1038/s41525-024-00438-4

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