Article
Longitudinal analyses of the DNA methylome in deployed military servicemen identify susceptibility loci for post-traumatic stress disorder.
Molecular psychiatry - 1 May 2018
Rutten B P F, Vermetten E, Vinkers C H, Ursini G, Daskalakis N P, Pishva E, de Nijs L, Houtepen L C, Eijssen L, Jaffe A E, Kenis G, Viechtbauer W, van den Hove D, Schraut K G, Lesch K-P, Kleinman J E, Hyde T M, Weinberger D R, Schalkwyk L, Lunnon K, Mill J, Cohen H, Yehuda R, Baker D G, Maihofer A X, Nievergelt C M, Geuze E, Boks M P M
Abstract excerpt
In order to determine the impact of the epigenetic response to traumatic stress on post-traumatic stress disorder (PTSD), this study examined longitudinal changes of genome-wide blood DNA methylation profiles in relation to the development of PTSD symptoms in two prospective military cohorts (one discovery and one replication data set). In the first cohort consisting of male Dutch military servicemen (n=93), the...
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