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Article

Elevated IgG levels induce an M2‑to‑M1 phenotypic shift in mucosal macrophages and restrict the growth of invasive sphenoid sinus pituitary adenomas.

Molecular medicine reports - 1 Jun 2026

Li Xingbo, Lei Zhuowei, Li Sihan, Xu Linpeng, Wang Quanji, Jiang Qian, Wang Zihan, Zhang Huaqiu, Huang Yimin, Lei Ting

Abstract excerpt

Although invasive pituitary adenomas (PAs) commonly invade the sellar floor and violate the dura mater, complete penetration of the sphenoid sinus mucosa is uncommon, and thus, mapping of the tumor‑mucosa immune landscape is warranted. In the present study, clinical PA specimens were analyzed via H&E staining, Masson's trichrome staining and immunohistochemistry. Spatial immune architecture and activation states...

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Source

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Identifiers

PMID: 41992957
DOI: 10.3892/mmr.2026.13878
PMCID: PMC13107097

Genes

CD47
STAT1
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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