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Article

Pituitary tumour fibroblast-derived cytokines influence tumour aggressiveness

23 Oct 2019

Abstract excerpt

Tumour-associated fibroblasts (TAFs) are key elements of the tumour microenvironment, but their role in pituitary neuroendocrine tumours (PitNETs) has been little explored. We hypothesised that TAF-derived cytokines may play a role in tumour aggressiveness and that their release can be inhibited by somatostatin analogues. TAFs were isolated and cultured from 16 PitNETs (11 clinically non-functioning tumours and 5...

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PMID: 31645017
DOI: 10.1530/erc-19-0327

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