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Article

Lactobacillus-derived indole-3-lactic acid suppresses meningioma malignant phenotypes by direct anti-proliferative effects and macrophage reprogramming.

Journal of translational medicine - 14 May 2026

Jiang Shucai, Shang Guanjie, Ning Weihai, Liu Deshan, Huang Jianhua, Lan Xiaoning, Bai Yu, Hao Yubing, Wang Haoran, Zhang Hongwei

Abstract excerpt

BACKGROUND: The intratumoral microbiome influences cancer progression, but its role in meningiomas is unknown. We characterized the meningioma intratumoral microbiome and investigated its functional significance. METHODS: 16 S rRNA sequencing was performed on 80 meningioma specimens (44 benign, 36 non-benign). Microbial findings were validated via fluorescence in situ hybridization (FISH) and transmission...

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Identifiers

PMID: 42135724
DOI: 10.1186/s12967-026-08222-x
PMCID: PMC13343675

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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