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Article

RHS-elements function as type II toxin-antitoxin modules that regulate intra-macrophage replication of Salmonella Typhimurium.

PLoS genetics - 1 Feb 2020

Stårsta Magnus, Hammarlöf Disa L, Wäneskog Marcus, Schlegel Susan, Xu Feifei, Heden Gynnå Arvid, Borg Malin, Herschend Sten, Koskiniemi Sanna

Abstract excerpt

RHS elements are components of conserved toxin-delivery systems, wide-spread within the bacterial kingdom and some of the most positively selected genes known. However, very little is known about how Rhs toxins affect bacterial biology. Salmonella Typhimurium contains a full-length rhs gene and an adjacent orphan rhs gene, which lacks the conserved delivery part of the Rhs protein. Here we show that, in addition...

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PMID: 32053596
DOI: 10.1371/journal.pgen.1008607
PMCID: PMC7043789

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