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Article

Integrating contextual determinants and polygenic risk to examine dementia and late-life cognition in the Multi-Ethnic Study of Atherosclerosis.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Apr 2026

Xue Diane, Hirsch Jana A, Besser Lilah, Hughes Timothy M, Blue Elizabeth E, Fitzpatrick Annette L, Fohner Alison E

Abstract excerpt

INTRODUCTION: Alzheimer's disease and related dementias are influenced by genetic and environmental risk factors. We investigated the relationship between contextual exposures and cognitive outcomes, independent of and in interaction with polygenic risk. METHODS: Using the Multi-Ethnic Study of Atherosclerosis (N = 5687), we assessed the associations of contextual determinants representing the social, chemical,...

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Identifiers

PMID: 41988869
DOI: 10.1002/alz.71384
PMCID: PMC13084535

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