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Article

MTHFR rs1801131 GG Genotype Combined with Serum LDH Level Predicts Lung Adenocarcinoma Susceptibility and Poor Prognosis in Guangxi Zhuang Population.

Cancer control : journal of the Moffitt Cancer Center - 1 Jan 2026

Zuo Chao, Wang Yuanyuan, Yang Dongli, Cheng Jing, Guo Mengna, Yang Zhuo, Wang Yu, Wang Feng, Qiao Yongchao

Abstract excerpt

IntroductionMethylenetetrahydrofolate reductase (MTHFR) polymorphisms modulate folate metabolism and carcinogenesis, yet their role in lung adenocarcinoma (LUAD) susceptibility and prognosis, particularly in underrepresented populations, remains unclear.MethodsWe conducted a retrospective case-control study of 306 lung cancer (LC) patients (predominantly LUAD) and 156 healthy controls of Guangxi Zhuang ethnicity,...

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PMID: 41987024
DOI: 10.1177/10732748261443869
PMCID: PMC13087326

Genes

MTHFR

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