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Article

Genetic variation in BCL2 3'-UTR was associated with lung cancer risk and prognosis in male Chinese population.

PloS one - 1 Jan 2013

Xu Ping, Liu Li, Wang Jianzhong, Zhang Kai, Hong Xiaohua, Deng Qifei, Xiang Jingjun, Zhang Xiaomin, He Meian, Wu Tangchun, Guo Huan

Abstract excerpt

OBJECTIVES: Bcl-2 is a critical apoptosis inhibitor with established carcinogenic potential, and can confer cancer cell resistance to therapeutic treatments by activating anti-apoptotic cellular defense. We hypothesized that genetic variants of BCL2 gene may be associated with lung cancer susceptibility and prognosis. METHODS: Three selected tagSNPs of BCL2 (rs2279115, rs1801018, and rs1564483) were genotyped in...

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Identifiers

PMID: 23977251
DOI: 10.1371/journal.pone.0072197
PMCID: PMC3745400

Genes

BCL2

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