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Genetic Insights Into Hypertension and Breast Cancer Risk in African Women: A Mendelian Randomization and Colocalization Analyses.

Annals of human genetics - 1 Jul 2026

Ansah Emmanuel Owusu, Agyenim Emmanuel Boateng, Danquah Andrews, Addo Stephen Kumi, Agyirifo Daniel Sakyi, Fosu Kwadwo, Kyei Foster

Abstract excerpt

BACKGROUND: Breast cancer (BC) is a major global health concern. Although observational studies have reported an association between hypertension and BC risk, the causal nature of this relationship remains unclear. METHODS: We performed a univariate two-sample Mendelian randomization (MR) analysis to investigate the causal effect of genetically predicted hypertension on overall BC risk and its molecular subtypes....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 41981879
DOI: 10.1111/ahg.70038

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