Article
Herpes simplex virus type 1 R-loops are targets for APOBEC-mediated mutagenesis.
Genome biology - 14 Apr 2026
Miskei Márton, Varga Dóra, Hornyák Lilla, Sipos Éva, Nagy Éva, Li Qiuzhen, Karányi Zsolt, Szabó Zoltán, DeWeerd Rachel, Green Abby M, Szüts Dávid, Csoma Eszter, Székvölgyi Lóránt
Abstract excerpt
APOBEC3 enzymes are key effectors of antiviral immunity that introduce mutations into viral genomes. We show that viral R-loops serve as preferred substrates for APOBEC3-mediated mutagenesis during herpes simplex virus type 1 (HSV-1) infection. APOBEC3 enzymes are recruited to viral R-loops, generating clustered C-to-T mutations in genes critical for viral assembly. Importantly, R-loops alone are not mutagenic,...
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