Article
Shared sequence characteristics identified in non-canonical rearrangements of HSV-1 genomes.
Journal of virology - 21 Dec 2023
Shitrit Alina, Nisnevich Valerya, Rozenshtein Nofar, Kobo Hila, Phan Hoang Van, Tay Savaş, Szpara Moriah, Weitzman Matthew D, Drayman Nir, Kobiler Oren
Abstract excerpt
IMPORTANCE: Mutations and genetic rearrangements are the primary driving forces of evolution. Viruses provide valuable model systems for investigating these mechanisms due to their rapid evolutionary rates and vast genetic variability. To investigate genetic rearrangements in the double-stranded DNA genome of herpes simplex virus type 1, the viral population was serially passaged in various cell types. The serial...
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