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The PARP inhibitor olaparib promotes senescence in murine macrophages

5 May 2025

Abstract excerpt

Cellular senescence is a multifaceted process involving cell cycle arrest, telomere shortening, and the accumulation of DNA damage associated with aging and cellular stress. It is marked by persistent cell cycle arrest and DNA damage accumulation, and plays an increasingly recognized role in age-related diseases and cancer therapy. Olaparib, a poly (ADP-ribose) polymerase (PARP) inhibitor, is approved for use in...

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PMID: 40327273
DOI: 10.1007/s11357-025-01679-6

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