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Article

Increased oxidative stress mediates the antitumor effect of PARP inhibition in ovarian cancer

30 Mar 2018

Abstract excerpt

PARP inhibitors have been widely tested in clinical trials, especially for the treatment of breast cancer and ovarian cancer, and were shown to be highly successful. Because PARP primarily functions in sensing and repairing DNA strand breaks, the therapeutic effect of PARP inhibition is generally believed to be attributed to impaired DNA repair. We here report that oxidative stress is also increased by PARP...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 29684820
DOI: 10.1016/j.redox.2018.03.016

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