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Article

Data-driven modelling of tau pathology reveals distinct progressive supranuclear palsy subtypes.

Brain : a journal of neurology - 7 Sept 2026

Cullinane Patrick W, Parmera Jacy Bezerra, Nelvagal Hemanth, Curless Toby, Chajed Leckhna Paras, Wrigley Sarah, Sifontes Valladares Walter, Burrows Maggie, Ebanks Kirsten, Wu Lesley, Binding Lawrence P, Anton Jaime, Revesz Tamas, Real Raquel, Vaughan David P, Jabbari Edwin, Morris Huw R, Brandner Sebastian, Young Alexandra L, Hoti Glen, Ma Yangxinrui, Bechtawi Mariam, Chiraki Nancy, de Pablo-Fernández Eduardo, Lim Yau Mun, Warner Thomas T, Jaunmuktane Zane

Abstract excerpt

Progressive supranuclear palsy (PSP) is a heterogeneous neurodegenerative disease characterized by the accumulation of misfolded 4-repeat tau within neurons and glial cells. There are limited longitudinal data on pathologically confirmed PSP patients with phenotypes other than classic Richardson's syndrome (RS) and the pathomechanisms responsible for the broad variability in clinical phenotype and progression are...

Read the complete abstract on PubMed

Topics

Humans
Supranuclear Palsy, Progressive
tau Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Female

Aged

Male

Middle Aged

Disease Progression

Brain

Phenotype

Aged, 80 and over

Tauopathies

Source

Open in PubMed Open full text

Identifiers

PMID: 41974128
DOI: 10.1093/brain/awag131
PMCID: PMC13548875

Genes

MAPT
APOE
SLC2A13
TRIM11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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