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Latent trait modeling of tau neuropathology in progressive supranuclear palsy

26 Feb 2021

Abstract excerpt

Abstract Progressive supranuclear palsy (PSP) is the second most common neurodegenerative Parkinsonian disorder after Parkinson’s disease, and is characterized as a primary tauopathy. Leveraging the considerable clinical and neuropathologic heterogeneity associated with PSP, we measured tau neuropathology as quantitative traits to perform a genome-wide association study (GWAS) within PSP to identify genes and...

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PMID: 33635380
DOI: 10.1007/s00401-021-02289-0

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