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Article

Integrated stress response genes as novel biomarkers and therapeutic targets in ankylosing spondylitis: a transcriptomic and Mendelian randomization study.

Frontiers in immunology - 1 Jan 2026

Wang Shuai, Zhu Jingliang, Zhang Honghui, Hu Shengxuan, Mei Jiaxin, Zhou Chusong, Shi Benchao

Abstract excerpt

Introduction: Ankylosing spondylitis (AS) is a chronic inflammatory disorder with poorly defined pathogenic mechanisms. The integrated stress response (ISR), an evolutionarily conserved signaling network, is implicated in AS development. This research endeavored to identify biomarkers for AS, thereby offering novel targets and approaches for therapeutic intervention. Methods: Transcriptomic profiling of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41972137
DOI: 10.3389/fimmu.2026.1718471
PMCID: PMC13062218

Genes

FBXO31
MSRB3
RORA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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