Article
Germline genetic patterns underlying familial rheumatoid arthritis, systemic lupus erythematosus and primary Sjögren's syndrome highlight T cell-initiated autoimmunity.
Annals of the rheumatic diseases - 1 Feb 2020
Wang Yukai, Chen Shaoqi, Chen Jingyao, Xie Xuezhen, Gao Sini, Zhang Chengpeng, Zhou Songxia, Wang Jing, Mai Ruiqin, Lin Qisheng, Lin Jianqun, Matucci-Cerinic Marco, Zhang Guohong, Furst Daniel E
Abstract excerpt
OBJECTIVES: Familial aggregation of primary Sjögren's syndrome (pSS), systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and co-aggregation of these autoimmune diseases (ADs) (also called familial autoimmunity) is well recognised. However, the genetic predisposition variants that explain this clustering remains poorly defined. METHODS: We used whole-exome sequencing on 31 families (9 pSS, 11 SLE, 6 RA...
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