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Article

NGS-Based Mutation Profiling and PD-L1 Expression in NSCLC Patients: A Single-Centre Prospective Analysis.

Turk patoloji dergisi - 1 Jan 2026

Sayyada Anab, Gautam Dheeraj, Sharma Rashi, Bhat Apeksha, Wadhwa Jyoti, Arya Mamta

Abstract excerpt

OBJECTIVE: Non-small cell lung cancer (NSCLC) is a molecularly heterogeneous disease in which both actionable mutations and PD-L1 expression influence therapeutic decisions. This study aimed to evaluate the molecular profile of NSCLC using next-generation sequencing (NGS) and analyse the association of PD-L1 expression with key genetic alterations. MATERIAL AND METHODS: A retrospective analysis was conducted on...

Read the complete abstract on PubMed

Topics

Humans
Carcinoma, Non-Small-Cell Lung
B7-H1 Antigen
Lung Neoplasms
Female
Male
Middle Aged

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Aged

High-Throughput Nucleotide Sequencing

Mutation

Adult

Retrospective Studies

Prospective Studies

DNA Mutational Analysis

Aged, 80 and over

Immunohistochemistry

Biomarkers, Tumor

Source

Open in PubMed Open full text

Identifiers

PMID: 41968881
DOI: 10.5146/tjpath.2026.14900
PMCID: PMC13600666

Genes

EGFR
KRAS
ALK
AR
BRAF
ERBB2
MET
ROS1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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