Article
Comprehensive molecular analysis of driver mutations in non-small cell lung carcinomas and its correlation with PD-L1 expression, An Indian perspective.
Pathology, research and practice - 1 Jan 2024
Aggarwal Aditi, Sharma Shivani, Brar Zoya, Kumar Vipin, Kumar Akash, Katara Rahul, Mohanty Sambit K
Abstract excerpt
BACKGROUND: The understanding of molecular mechanisms involved in non-small cell lung carcinoma (NSCLC) has revolutionized significantly in the recent years. These have helped to develop personalized management strategies by identifying specific molecular alterations such as mutations in EGFR, ROS1, BRAF, ERBB2, MET, ALK, and KRAS genes. These mutations are targetable ensuring a better clinical outcome....
Topics
- Male
- Female
- Humans
- Aged
- Carcinoma, Non-Small-Cell Lung
- Lung Neoplasms
- Proto-Oncogene Proteins B-raf
- B7-H1 Antigen
- Reproducibility of Results
- Mutation
- Proto-Oncogene Proteins
- Protein Kinase Inhibitors
- Carcinoma