Article
Profiling non-small cell lung cancer reveals that PD-L1 is associated with wild type EGFR and vascular invasion, and immunohistochemistry quantification of PD-L1 correlates weakly with RT-qPCR.
PloS one - 1 Jan 2021
Alwithenani Akram, Bethune Drew, Castonguay Mathieu, Drucker Arik, Flowerdew Gordon, Forsythe Marika, French Daniel, Fris John, Greer Wenda, Henteleff Harry, MacNeil Mary, Marignani Paola, Morzycki Wojciech, Plourde Madelaine, Snow Stephanie, Marcato Paola, Xu Zhaolin
Abstract excerpt
Most lung cancer patients are diagnosed at an advanced stage, limiting their treatment options with very low response rate. Lung cancer is the most common cause of cancer death worldwide. Therapies that target driver gene mutations (e.g. EGFR, ALK, ROS1) and checkpoint inhibitors such anti-PD-1 and PD-L1 immunotherapies are being used to treat lung cancer patients. Identification of correlations between driver...
Topics
- Adult
- Aged
- Aged, 80 and over
- B7-H1 Antigen
- Carcinoma, Non-Small-Cell Lung
- ErbB Receptors
- Female
- Humans
- Lung Neoplasms