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Oral Mucositis in Oncopediatric Patients: MTX and MMP-1, MMP-8, MMP-13 Gene Polymorphisms.

Oral diseases - 1 May 2026

Ribeiro Nicole Januário, Tissi Larissa Helena, Escobar Mateus Tissot, Valença Ana Maria Gondim, Souza Ricardo Lehtonen Rodrigues, de Oliveira Naila Francis Paulo, Santos Maria Cristina Leme Godoy

Abstract excerpt

BACKGROUND: This study investigates the association between single-nucleotide polymorphisms (SNPs) in the MMP-1, MMP-8, and MMP-13 genes and the risk of oral mucositis development in paediatric patients with leukaemia and lymphoma who are undergoing methotrexate (MTX) treatment. MTX is associated with inflammatory effects and oxidative stress, which activate MMPs, enzymes responsible for degrading the...

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Antimetabolites, Antineoplastic
Child, Preschool
Leukemia
Lymphoma
Matrix Metalloproteinase 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Matrix Metalloproteinase 13

Matrix Metalloproteinase 8

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PMID: 41968470
DOI: 10.1111/odi.70195
PMCID: PMC13364997

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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