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Integrative bioinformatics and machine learning reveal hub genes and immune signatures bridging type 2 diabetes mellitus, fracture susceptibility, and osteoblast differentiation dysfunction

2026-06-04

Abstract excerpt

<title>Abstract</title> <p>To explore the causal link between T2DM and fracture, identify hub genes connecting T2DM, osteoblast differentiation, and fracture, and elucidate the molecular mechanisms behind T2DM-impaired fracture healing. We employed two-sample MR based on GWAS data to evaluate the causal effect of T2DM on fracture. By integrating gene expression data related to T2DM, fractures, and osteoblast diff...

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Literature Corpus work: afbab512-8f4e-557c-9a03-10d18057f6d1
DOI: 10.21203/rs.3.rs-9655784/v1

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Integrative bioinformatics and machine learning reveal hub genes and immune signatures bridging type 2 diabetes mellitus, fracture susceptibility, and osteoblast differentiation dysfunctionDOI 10.21203/rs.3.rs-9655784/v1Read

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