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Article

Sex-specific associations of physical frailty with cardiac structure and function: a cross-sectional study based on UK Biobank.

BMC cardiovascular disorders - 9 Apr 2026

Liu Gejing, Guo Shunlin

Abstract excerpt

BACKGROUND: Frailty, characterized by diminished physiological reserves and heightened vulnerability to adverse health outcomes, is a robust predictor of cardiovascular morbidity and mortality that extends beyond chronological age. Preclinical studies in aging mouse models have demonstrated that frailty—rather than age alone—drives adverse cardiac remodeling with distinct sex-specific patterns: ventricular...

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Identifiers

PMID: 41957717
DOI: 10.1186/s12872-026-05737-5
PMCID: PMC13255337

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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