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Article

Frailty and heart failure: Clinical impact, biomarkers, and phenotypic differences.

The American journal of the medical sciences - 1 Oct 2026

Katib Husam, Pandya Naushira, Guida Vincent, Masri Hady

Abstract excerpt

Frailty is a multidimensional geriatric syndrome characterized by reduced physiologic reserve and increased vulnerability to stressors. Its prevalence is particularly high among patients with heart failure (HF), reflecting the interplay between aging, multimorbidity, and chronic cardiovascular disease. Frailty independently predicts poor outcomes, including higher hospitalization rates, mortality, and impaired...

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Topics

Humans
Heart Failure
Frailty
Biomarkers
Phenotype
Stroke Volume
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Identifiers

PMID: 42288260
DOI: 10.1016/j.amjms.2026.06.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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