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Article

Serological and Genetic Evidence for Altered Complement System Functionality in Systemic Lupus Erythematosus: Findings of the GAPAID Consortium.

PloS one - 1 Jan 2016

Prechl József, Papp Krisztián, Hérincs Zoltán, Péterfy Hajna, Lóránd Veronika, Szittner Zoltán, Estonba Andone, Rovero Paolo, Paolini Ilaria, Del Amo Jokin, Uribarri Maria, Alcaro Maria Claudia, Ruiz-Larrañaga Otsanda, Migliorini Paola, Czirják László

Abstract excerpt

Systemic lupus erythematosus is a chronic autoimmune disease with multifactorial ethiopathogenesis. The complement system is involved in both the early and late stages of disease development and organ damage. To better understand autoantibody mediated complement consumption we examined ex vivo immune complex formation on autoantigen arrays. We recruited patients with SLE (n = 211), with other systemic autoimmune...

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PMID: 26950932
DOI: 10.1371/journal.pone.0150685
PMCID: PMC4780778

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Source receipt: pubmed, retrieved 6 Sept 2026.

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