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Article

Idiopathic Pulmonary Fibrosis: Molecular Endotypes of Fibrosis Stratifying Existing and Emerging Therapies.

Respiration; international review of thoracic diseases - 1 Jan 2017

Magnini Daniele, Montemurro Giuliano, Iovene Bruno, Tagliaboschi Linda, Gerardi Rafael Emanuele, Lo Greco Erminia, Bruni Teresa, Fabbrizzi Alessio, Lombardi Francesco, Richeldi Luca

Abstract excerpt

Idiopathic pulmonary fibrosis (IPF) is a specific form of chronic, progressive fibrosing interstitial pneumonia of unknown causes. Current diagnostic criteria are based on radiological, clinical, and histopathological features but, unfortunately, still many patients remain undiagnosed. Two currently approved therapies, pirfenidone and nintedanib, slow down disease progression but failed to block or revert it. On...

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PMID: 28472808
DOI: 10.1159/000475780

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