Pathogenesis and immune regulation of rheumatoid arthritis-associated interstitial lung disease: from basic research to clinical implications.

doi:10.3389/fimmu.2026.1770348

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Article

Pathogenesis and immune regulation of rheumatoid arthritis-associated interstitial lung disease: from basic research to clinical implications.

Frontiers in immunology - 1 Jan 2026

Cheng Yaxin, Shan Yu, Zheng Yixin, Zhao Fuyu, Shi Yiming, Song Chenyang, Li Yunshen, Zhao Jianan, Chang Cen, Wang Yuguang, He Dongyi

Abstract excerpt

Interstitial lung disease (ILD) is one of the most common extra-articular manifestations of rheumatoid arthritis (RA). Some patients with RA-ILD may develop progressive pulmonary fibrosis, leading to severe impairment of lung function and respiratory failure, which impacts quality of life and can even be life-threatening. This review identified genetic susceptibility, environmental factors, and immune...

Topics

Humans
Arthritis, Rheumatoid
Lung Diseases, Interstitial
Animals
Autoantibodies
Genetic Predisposition to Disease

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Identifiers

PMID: 41909710
DOI: 10.3389/fimmu.2026.1770348
PMCID: PMC13021622

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