The AGPS regulatory variant rs113671272 confers esophageal squamous cell carcinoma susceptibility through allele-specific MEIS3 binding and NF-κB activation in Chinese populations.

doi:10.1016/j.ebiom.2026.106249

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The AGPS regulatory variant rs113671272 confers esophageal squamous cell carcinoma susceptibility through allele-specific MEIS3 binding and NF-κB activation in Chinese populations.

EBioMedicine - 1 May 2026

Fang Xumeng, Deng Jiaying, Liu Ming, Tan Wen, Wang Mengyun, Wu Yuanna, Zhao Kuaile

Abstract excerpt

BACKGROUND: Esophageal squamous cell carcinoma (ESCC) demonstrates pronounced ethnic disparities, being prevalent in Asian populations. However, the genetic mechanisms underlying this disparity remain poorly understood. This study aims to characterise the functional contribution of the regulatory variant rs113671272 in alkylglycerone phosphate synthase (AGPS) to ESCC susceptibility and prognosis in Chinese...

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Identifiers

PMID: 41950565
DOI: 10.1016/j.ebiom.2026.106249
PMCID: PMC13090961

Genes

AGPS
MEIS3

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