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Article

Molecular and Cell Biological Characterization of Patient-Derived Head and Neck Squamous Carcinoma Cell Lines.

Cancer science - 1 Jun 2026

Ito Kazue, Ishida Noriko, Ito Shin, Shindo Norihisa, Souma Satoshi, Mochizuki Mai, Fujimori Haruna, Tamai Keiichi, Imai Takayuki, Yamazaki Tomoko, Yamaguchi Kazunori, Sasaki Kento, Miyakura Yuya, Murakami Shigekazu, Unno Yuka, Asano Naoki, Asada Yukinori, Yasuda Jun

Abstract excerpt

Head and neck squamous cell carcinoma (HNSCC) is a major cancer among head and neck malignancies with a limited availability of effective molecularly targeted therapies. The underlying oncogenic mechanisms, however, remain poorly understood. To investigate patient-specific molecular targets, we established patient-derived cell (PDC) lines from surgically resected HNSCC tissue samples. We performed comprehensive...

Topics

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Chromosome Segregation
Class I Phosphatidylinositol 3-Kinases
Gene Expression Regulation, Neoplastic
Head and Neck Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Precision Medicine

Squamous Cell Carcinoma of Head and Neck

Source

Identifiers

PMID: 41948974
DOI: 10.1111/cas.70365

Genes

PDC
CCND1
EGFR
FGFR2
KIF18A
PIK3CA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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